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Biomarker Trajectories Detailed biomarker analyses from SELECT showed the following trajectories: An important observation is that the CRP reduction was rapid (most of the reduction occurred within the first 20 weeks) and was maintained throughout the trial, whereas weight loss continued to accrue through week 52

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Evidence from experiments employing somatostatin receptor 2 (SSRT2) antagonists and SSRT2 knockout mice strongly suggests that GLP-1’s inhibitory actions on α-cells are indirect and partially mediated through somatostatin-dependent mechanisms (132)